OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
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Enhancing T cell affinity discrimination to reduce the cross-reactivity of T cell therapies
A single T cell receptor (TCR) can recognise up to one million different peptide ligands with varying affinities. We have developed a novel high-throughput Surface Plasmon Resonance (SPR) method to measure the affinity of hundreds of TCR/pMHC interactions in a single experiment. Using this method, we demonstrate that T activation correlates with ligand affinity. Furthermore, we have shown that modifying co-signalling receptors can selectively abolish T cell activation against low-affinity peptide. Overall, these findings demonstrate that T cells can be engineered to be less cross-reactive, which has important implications for enhancing the safety of adoptive T cell therapies.
Date:
2 June 2025, 13:00
Venue:
Online
Speaker:
Jose Cabezas Caballero (Dushek Group, University of Oxford)
Organiser:
Hashem Koohy (University of Oxford)
Organiser contact email address:
sally.pelling-deeves@medsci.ox.ac.uk
Host:
Hashem Koohy (University of Oxford)
Part of:
Unravelling T Cell Recognition: Insights from Immunology and AI
Booking required?:
Required
Booking url:
https://events.teams.microsoft.com/event/f3e9b4c6-dfe9-419c-8a5e-db867bfe6f92@cc95de1b-97f5-4f93-b4ba-fe68b852cf91
Cost:
Free
Audience:
Members of the University only
Editor:
Sally Pelling-Deeves
