Illuminating Biochemical Activity Architecture of the Cell
The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. We have developed a series of fluorescent biosensors to probe the compartmentalized signaling activities. In this talk, I will focus on cAMP/PKA and PI3K/Akt/mTORC1 signaling pathways and present studies where we combined genetically encoded fluorescent biosensors, superresolution imaging, and targeted biochemical perturbations to probe the biochemical activity architecture of the cell.
Date: 15 September 2017, 13:00 (Friday, 21st week, Trinity 2017)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Large Lecture Theatre
Speaker: Jin Zhang (University of California)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organisers: Sara Bouskela (University of Oxford, Department of Physiology Anatomy and Genetics (DPAG)), Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Part of: Cell Physiology Theme Guest Speakers (DPAG)
Booking required?: Not required
Audience: Members of the University only
Editor: Victoria Bullett