The Ludwig EpiCancer Symposium is focussed on understanding the impact of non-genetic mechanisms on cancer progression, including: epigenetics,epitranscriptomics, non-coding RNAs, protein translation, metabolism and interaction between the microenvironment and cancer cell plasticity. The meeting will bring together world-leadings scientists in each of these areas with the aim of fostering greater understanding of the disease, promoting synergies, and identifying novel therapeutic vulnerabilities.