OxTalks is Changing
On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Neuronal genome integrity and plasticity
Please note that this is an Ad Hoc seminar.
This is a hybrid event - with the speaker attending in-person and viewable on Teams.
The DNA of neurons is continually damaged due to lifelong, high-level metabolic and transcriptional activity. In addition, recent studies have demonstrated extensive “programmed” DNA damage in differentiating post-mitotic neurons. Here, we identify these endogenous lesions as single strand break intermediates of thymine DNA glycosylase (TDG)-mediated removal of oxidized methylcytosines at neuronal enhancers. Interrupting active DNA demethylation using anti-neoplastic cytosine analogs triggers TDG-dependent neuronal cell death associated with massive chromosomal rearrangements of neuronal enhancers. This suggests that the well-known neurotoxic side effects of certain chemotherapies, also called “chemobrain,” could be linked to DNA repair processes intrinsic to normal neuronal differentiation. We will discuss recent studies that describe the interplay between programmed DNA damage, cell fate specification and mutagenesis in post-mitotic neurons.
Date:
19 May 2023, 13:00
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
Seminar Room
Speaker:
Dr. Andre Nussenzweig (Branch Chief of the Laboratory of Genome Integrity at the Center for Cancer Research, National Cancer Institute, National Institutes of Health in Bethesda, Maryland)
Organising department:
MRC Weatherall Institute of Molecular Medicine
Organiser:
Yasmine Saito (Weatherall Institute, University of Oxford)
Organiser contact email address:
seminar.admin@imm.ox.ac.uk
Host:
Dr Ewa Gogola (University of Oxford)
Part of:
WIMM THURSDAY SEMINARS
Booking required?:
Required
Booking email:
seminar.admin@imm.ox.ac.uk
Audience:
Members of the University only
Editors:
Emma Brayne,
Karin McLeod,
Yasmine Saito
