Robust MAIT cell activation in response to interactions with primary human liver cell subsets
Please arrive 5 minutes before the start of the talk to gain access to the building
Mucosal-associated invariant T (MAIT) cells represent the most abundant T cell type in human liver. Activated MAIT cells are able to secrete IL-17, a cytokine known to exert pro-fibrotic functions. In order to understand which cells in the liver are involved in MAIT cell activation, we are applying naturally occurring antigens (Ag) and defining Ag-presentation capacities of primary human liver cell subsets, both parenchymal and non-parenchymal, to human MAIT cells. We also study MAIT cell localization in human liver tissue, as assessed by immunofluorescence staining. Further, we are interested to explore occupancy of the Ag-presenting molecule MR1 with non-stimulatory ligands as a therapeutic strategy to prevent pro-fibrogenic properties of MAIT cells.
Date: 26 June 2019, 12:00 (Wednesday, 9th week, Trinity 2019)
Venue: Medawar Building, off South Parks Road OX1 3SY
Venue Details: Level 30 Seminar room
Speakers: Magdalena Filipowicz Sinnreich (Research Group Leader,University Hospital Basel ), Martin Lett (University Hospital Basel)
Organising department: Nuffield Department of Clinical Medicine
Organiser: Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Organiser contact email address:
Host: Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Part of: Peter Medawar Building Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Suki Kenth