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Robust MAIT cell activation in response to interactions with primary human liver cell subsets
Please arrive 5 minutes before the start of the talk to gain access to the building
Mucosal-associated invariant T (MAIT) cells represent the most abundant T cell type in human liver. Activated MAIT cells are able to secrete IL-17, a cytokine known to exert pro-fibrotic functions. In order to understand which cells in the liver are involved in MAIT cell activation, we are applying naturally occurring antigens (Ag) and defining Ag-presentation capacities of primary human liver cell subsets, both parenchymal and non-parenchymal, to human MAIT cells. We also study MAIT cell localization in human liver tissue, as assessed by immunofluorescence staining. Further, we are interested to explore occupancy of the Ag-presenting molecule MR1 with non-stimulatory ligands as a therapeutic strategy to prevent pro-fibrogenic properties of MAIT cells.
Date:
26 June 2019, 12:00
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Level 30 Seminar room
Speakers:
Magdalena Filipowicz Sinnreich (Research Group Leader,University Hospital Basel ),
Martin Lett (University Hospital Basel)
Organising department:
Nuffield Department of Clinical Medicine
Organiser:
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Organiser contact email address:
suki.kenth@ndm.ox.ac.uk
Host:
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Part of:
Peter Medawar Building Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Suki Kenth
