OxTalks is Changing
OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected to start before the end of Hilary Term to allow all future events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed on the Staff Gateway and via email to identified OxTalks users.
If you have any questions, please contact halo@digital.ox.ac.uk
Proteus mirabilis copper resistance protein is a shape-shifting redox foldase
Status: This talk is in preparation - details may change
In the hunt for targets for a new class of antibacterials to overcome antibiotic resistance, we stumbled across an extraordinary shape-shifting protein. Proteus mirabilis ScsC – which supports bacterial swarming motility under copper stress – is a disulfide isomerase. Previously characterised bacterial disulfide isomerases are dimeric quality control agents that shuffle incorrect disulfide bonds in misfolded proteins. Unexpectedly, we show that PmScsC is not a dimer – but a trimer. We solved three crystal structures of PmScsC, revealing that it undergoes extraordinary twisting and extending motions. These motions – that underpin the function of PmScsC – are a consequence of a short, highly flexible shape-shifting motif resulting in major changes to the overall dimensions of the proteins, almost doubling its length in one dimension.
Date:
8 June 2016, 12:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting Room A/B
Speaker:
Prof Jennifer Martin (The University of Queensland in Australia)
Organising department:
Wellcome Trust Centre for Human Genetics
Organiser:
Agata Krupa (Wellcome Trust Centre for Human Genetics)
Organiser contact email address:
jones-pa@strubi.ox.ac.uk
Host:
Prof E.Yvonne Jones (University of Oxford)
Part of:
Strubi seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Agata Krupa
