Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
Beta2 glycoprotein I (β2GPI) is an abundant plasma protein composed of 5 domains. The C-terminal disulphide bond is susceptible to cleavage by oxidoreductases. Certain biological functions of β2GPI depend on the redox form of the molecule. Nitric oxide metabolism has been shown to be disrupted in APS patients. We found that nitration of β2GPI occurs in-vivo and in-vitro in patients with APS and SLE and the nitrated form of the molecule alters its biological function. A novel assay was developed to quantify nitrated β2GPI levels. These were raised in patients with autoimmune disease compared to healthy and clinical event controls.
