Modeling muscle disease and regeneration in zebrafish
Status: This talk is in preparation - details may change
Status: This talk has been cancelled
This Seminar has unfortunately been CANCELLED.
Zebrafish possess a number of specific advantages for the study of muscle cell disease and regeneration. Foremost amongst these attributes is the fact that the externally-developing, transparent, zebrafish embryo and larva allows simple optical inspection of living muscle. Using both forward and reverse genetic approaches we have generated mutations in the zebrafish orthologues of the vast majority of human dystrophy disease-causing genes. Using this resource, we have sought to understand the basis for the pathology evident in the least well understood of the inherited muscle diseases. Amongst the most enigmatic of the dystrophies at the mechanistic level are those grouped as the Congenital Muscular Dystrophy class. Here I describe our studies, that use the image intensive and genetic approaches that are facilitated in the zebrafish system, coupled with studies in patient cells, to make novel insights in to the pathological basis of a number of these disorders. I will also describe our contributions to the understanding of the muscle regenerative process, a focus of the laboratory that aims to document and understand the collective cellular response triggered in muscle disease and tissue injury.
20 March 2020, 11:00 (Friday, 9th week, Hilary 2020)
Sherrington Building, off Parks Road OX1 3PT
Sherrington Room, Sherrington Building, Parks Road (entrance on Sherrington Road), OX1 3PT
Prof Peter D. Currie (Director of Research, Australian Regenerative Medicine Institute. Head, EMBL Australia Melbourne Node. NHMRC Senior Principal Research Fellow. Level 1, 15 Innovation Walk Monash University, Wellington Road Clayton VIC 3800. Australia.)
Department of Paediatrics
Organiser contact email address:
Kay Davies (University of Oxford)
MDUK Oxford Neuromuscular Centre Seminars
Members of the University only
Nicole Le Grand