Sympathetic neuroimmune interactions regulating outcomes of viral infection and cancer
In-person only
Crosstalk between sympathetic nerves and immune cells is increasingly recognised as a crucial process for protection and recovery from viral infections and cancers. Yet, how sympathetic signalling alters immunity is still relatively poorly understood. We are using contemporary neuroscience tools to map neuron subsets that innervate lymphoid organs and tumours and define mechanisms of sympathetic neuroimmune crosstalk. Using chemogenetic and transgenic mouse models, intravital imaging, single cell transcriptomics and quantitative spatial imaging we describe dynamic modulation of neuronal functions by immune responses and reciprocal regulation of immune responses by sympathetic neurons.
Date: 8 July 2024, 12:00 (Monday, 12th week, Trinity 2024)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Kennedy Lecture Theatre
Speaker: Prof Scott Mueller (University of Melbourne)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
Hosts: Professor Christopher Buckley (Kennedy Institute of Rheumatology, University of Oxford), Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Doris Chan