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From Nuclear Swelling to Chemoattractant Production During Tissue Damage
In person only
Upon tissue damage, inflammatory signals and chemoattractants drive leukocyte recruitment and initiate host defense mechanisms. These are particularly crucial in injured epithelia to protect against environmental threats and pathogen invasion. Our research has demonstrated the central role of cytosolic phospholipase A2 (cPLA2)-dependent eicosanoid production in this process. Triggered by nuclear swelling and damage-induced Ca2+ signaling, cPLA2 and 5-lipoxygenase (5-LOX) contribute to the production of inflammatory eicosanoids. To further elucidate chemoattractant dynamics, in a project called „Inflamapping” we have begun developing a suite of GPCR-based fluorescent biosensors to visualize gradients of key chemoattractants, including LTB4, fMLP, and C5a.
Date:
28 October 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Balázs Enyedi (Semmelweis University, Hungary)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
