Cis-regulation dynamics and chromatin architecture during development and evolution
The Gomez-Skarmeta group combines epigenomics, chromosome capture assays, transgenic enhancer experiments and mutagenic studies to determine how cis-regulatory elements and chromatin structure contribute to development and evolution, and how alteration in this non-coding part of the genome affects human health. For example, by genome-wide interrogation of histone marks associated with enhancers and promoters in zebrafish, they determined, for the first time in a vertebrate embryo, the dynamics of enhancer activity during early embryogenesis. In addition, they are applying 4C-Seq to systematically determine the gene regulatory landscapes of key developmental genes in embryos of different species. Projects in the lab also investigate the role of mutations in cis-regulatory elements in human disease.
Date: 21 January 2016, 11:00 (Thursday, 1st week, Hilary 2016)
Venue: NDM Building, Headington OX3 7FZ
Venue Details: Basement Seminar Room
Speaker: Dr Jose Luis Gomez Skarmeta (Centro Andaluz de Biología del Desarrollo, Seville)
Organising department: Ludwig Institute for Cancer Research, Oxford Branch
Organisers: Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine), Alexandra Ward (University of Oxford, Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address:
Host: Dr Sarah De Val (LICR, University of Oxford)
Part of: Ludwig Institute Seminar Series
Topics: Genetic regulation, Epigenetics, Cancer, Evolution
Booking required?: Not required
Audience: Members of the University only
Editor: Mary Muers