Cis-regulation dynamics and chromatin architecture during development and evolution
ALL WELCOME
The Gomez-Skarmeta group combines epigenomics, chromosome capture assays, transgenic enhancer experiments and mutagenic studies to determine how cis-regulatory elements and chromatin structure contribute to development and evolution, and how alteration in this non-coding part of the genome affects human health. For example, by genome-wide interrogation of histone marks associated with enhancers and promoters in zebrafish, they determined, for the first time in a vertebrate embryo, the dynamics of enhancer activity during early embryogenesis. In addition, they are applying 4C-Seq to systematically determine the gene regulatory landscapes of key developmental genes in embryos of different species. Projects in the lab also investigate the role of mutations in cis-regulatory elements in human disease.
Date:
21 January 2016, 11:00 (Thursday, 1st week, Hilary 2016)
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
Basement Seminar Room
Speaker:
Dr Jose Luis Gomez Skarmeta (Centro Andaluz de Biología del Desarrollo, Seville)
Organising department:
Ludwig Institute for Cancer Research, Oxford Branch
Organisers:
Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine),
Alexandra Ward (University of Oxford, Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address:
alexandra.ward@ludwig.ox.ac.uk
Host:
Dr Sarah De Val (LICR, University of Oxford)
Part of:
Ludwig Institute Seminar Series
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Mary Muers
