Moving beyond injury: Prenatal hypoxia ischemia diffusely disrupts cerebral development via neuronal dysmaturation
Survivors of preterm birth commonly display diffuse disturbances in cerebral growth that involve multiple cortical and subcortical structures. The basis of this impaired growth has commonly been attributed to widespread neuronal degeneration at a critical window in cerebral development. Our recent studies have found that immature cerebral neurons in the cortex, subplate and basal ganglia are surprisingly resistant to cell death at a time in development when the preterm white matter is particularly susceptible to moderately severe ischemia that triggers degeneration of oligodendrocyte progenitors. Nevertheless, a transient ischemic insult causes persistent disturbances in neuronal maturation, which have been defined by morphometry and electrophysiology.
Date:
15 June 2016, 16:00 (Wednesday, 8th week, Trinity 2016)
Venue:
Le Gros Clark Building, off South Parks Road OX1 3QX
Venue Details:
Large Lecture Theatre, Le Gros Clark Building, Department of Physiology, Anatomy and Genetics, University of Oxford
Speaker:
Stephen A. Back, M.D., Ph.D (Professor of Pediatrics and Neurology, Oregon Health & Science University, Clyde and Elda Munson Professor of Pediatric Research)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Professor Zoltan Molnar (DPAG, University of Oxford)
Organiser contact email address:
zoltan.molnar@dpag.ox.ac.uk
Host:
Professor Zoltan Molnar (DPAG, University of Oxford)
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Victoria Bullett
