Myeloid cell lifespan, death and activation in cancer inflammation

Peter Murray studies regulation of innate immune responses, with a particular focus on macrophage activation and deactivation because these cells are principally responsible for driving inflammation in many infections and other chronic and acute diseases. The innate immune response is subject to an extraordinarily complex series of regulatory events to maximize anti-pathogen responses but also to constrain the deleterious effects of innate immune response-driven inflammation. Questions his group are addressing include: what are the origins and fates of the different immune cells before, during and after attempts to clear the insult; what are the signals in local microenvironments perpetuating inflammation; and what are the signals given and received by macrophages enabling the switches between resolving and non-resolving inflammation? Answering these questions will point to macrophage-dependent signaling pathways amenable to therapeutic intervention.