Self-renewal of human hematopoietic progenitor cells: Development of novel therapies erythropoietin-resistant anemias

Harvey Lodish is a world-expert in haematopoiesis, particularly focusing on red blood cell development. A major focus is identifying genes and extracellular signals that regulate the self- renewal, proliferation, and differentiation of early erythroid progenitor cells; extracellular signals include activators of the glucocorticoid and PPAR receptors and oxygen. This work has led to the characterization of several molecules, including six that are FDA-approved drugs for other indications that show great promise as therapeutics for bone marrow failure disorders and erythropoietin- resistant anemias. This research involves extensive computational analyses of large datasets of gene expression profiles and chromatin modifications generated from cells at different stages of human and mouse red cell development.