Engineering brain activity patterns for therapeutics of disorders
Brain networks are disrupted in numerous disorders. We will first show how the aberrant brain-wide activity patterns can be corrected by targeting distinct network motifs with multiple neuromodulators using a zebrafish model of human epilepsy and autism. This systematic approach rescues behaviour unlike any other treatment resulting from large-scale drug screens. With methods promising future therapeutic use, we will next show how specific molecular targets in different brain circuits in mammals can be non-invasively and spatially targeted, and discuss how cortex-wide activity patterns can be captured chronically at single neuron resolution with minimal invasiveness using neuromorphic microchips.
Date: 3 May 2019, 13:00 (Friday, 1st week, Trinity 2019)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Large Lecture Theatre
Speaker: Prof. Dr. Mehmet Fatih Yanik (Institute of Neuroinformatics, ETH Zurich)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organisers: Cortex Club (University of Oxford), Professor Kristine Krug (DPAG, University of Oxford)
Organiser contact email address: hod-pa@dpag.ox.ac.uk
Host: Cortex Club (University of Oxford)
Part of: DPAG Head of Department Seminar Series
Topics: Neurosciences
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith