Engineering brain activity patterns for therapeutics of disorders
Brain networks are disrupted in numerous disorders. We will first show how the aberrant brain-wide activity patterns can be corrected by targeting distinct network motifs with multiple neuromodulators using a zebrafish model of human epilepsy and autism. This systematic approach rescues behaviour unlike any other treatment resulting from large-scale drug screens. With methods promising future therapeutic use, we will next show how specific molecular targets in different brain circuits in mammals can be non-invasively and spatially targeted, and discuss how cortex-wide activity patterns can be captured chronically at single neuron resolution with minimal invasiveness using neuromorphic microchips.
Date:
3 May 2019, 13:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Large Lecture Theatre
Speaker:
Prof. Dr. Mehmet Fatih Yanik (Institute of Neuroinformatics, ETH Zurich)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organisers:
Cortex Club (University of Oxford),
Professor Kristine Krug (DPAG, University of Oxford)
Organiser contact email address:
hod-pa@dpag.ox.ac.uk
Host:
Cortex Club (University of Oxford)
Part of:
DPAG Head of Department Seminar Series
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Talitha Smith