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Integrative multiscale approach to Parkinson’s disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. Despite intensive research over the last decades, our understanding of the complex disease progression is still rather limited. The talk will show how we use longitudianal multiomics characterization of patient-based induced pluripotent stem cells to identify underlying mechanisms of PD development in a top-down approach, and how the identified core mechanism of calcium-mediated mitochondrial control can be mechanistically investigated by combining experiments with computational modelling in an integrative bottom-up approach.
Date:
18 February 2026, 15:30
Venue:
Sir William Dunn School of Pathology, South Parks Road OX1 3RE
Venue Details:
EPA Seminar Room
Speaker:
Dr Alex Skupin (University of Luxembourg)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Professor Matthew Freeman (Sir William Dunn School of Pathology, University of Oxford)
Organiser contact email address:
path1429@ox.ac.uk
Host:
Professor Matthew Freeman (Sir William Dunn School of Pathology, University of Oxford)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Helly Worsdell
