OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Fertilization triggers drastic epigenetic reprogramming that converts terminally differentiated oocyte and sperm to totipotent embryos. However, how chromatin is reprogrammed at the DNA level in early mammalian development is poorly understood. Furthermore, whether histone modifications, the crucial epigenetic regulators, can be passed on from parents to the next generation is a long-standing question that remains elusive. By developing cutting-edge technologies, we recently investigated dynamic regulation of chromatin and histone modifications from gametes to early embryos in mice. In addition, we also showed how parental memory is controlled by a simple isoform switch of an epigenetic regulator. Our studies not only revealed extremely dynamic, non-canonical epigenomic reprogramming that accompanies early embryogenesis, but also shed lights on the fundamental principles underlying epigenetic inheritance between generations.
