OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Autophagy is a highly regulated cellular degradation system that engulfs cytosol, organelles, protein aggregates and invading microorganisms into a double-membrane vesicle termed the autophagosome, then delivers cargo to endolysosomes for degradation. Autophagy dysfunction has been implicated in a broad spectrum of human diseases, including cancers, neurodegeneration, infectious diseases, metabolic diseases and aging. My lab focuses on the biochemical mechanisms of autophagosome biogenesis, substrate recruitments and autophagosome fusion with lysosomes. We have identified and characterized novel protein factors (ATG14, NRBF2, TECPR1, OFD1 etc.,) essential for autophagy initiation, cargo recruitment and autophagosome-lysosome fusion (PNAS 2008,2010, 2012, Nature 2013, 2015, Mol Cell 2012).
