Innate host defence: a playing field for the ubiquitin machinery
The Gyrd-Hansen laboratory studies molecular mechanisms governing pro-inflammatory signalling during innate immune responses. Through this, they aim to understand the molecular mechanisms that on one hand protect against pathogens, but that also contribute to chronic inflammation, tumor development and cancer progression. A central focus of the lab is to elucidate the role and regulation of non-degradative ubiquitin modifications in these processes. Ultimately, they aim to identify ubiquitin-handling factors that can be targeted to modulate inflammation and antagonize cancer. Professor Gyrd-Hansen’s recent work has focused on the role of Met1-linked ubiquitin chains (also known as linear ubiquitin chains) in inflammatory signaling. These chains are generated by the Linear UBiquitin Assembly Complex (LUBAC), which is a key component of inflammatory signaling pathways, including those activated downstream of the cytoplasmic PRRs NOD1 and NOD2 that serve as sensors for intracellular bacteria. They have uncovered and characterised several factors that regulate the function of LUBAC in signaling. Future work in the group will focus on elucidating the function, regulation and interplay of individual ubiquitin chain types (of which there are at least eight) in the cellular response to infection.
Date: 13 November 2017, 12:00 (Monday, 6th week, Michaelmas 2017)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Dr Mads Gyrd Hansen (Ludwig Cancer Research)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Professor Irina Udalova (Kennedy Institute of Rheumatology), Jo Silva (NDORMS), Wulf Forrester-Barker (University of Oxford, Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences), Laura Hume (Kennedy Institute of Rheumatology)
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Laura Sanchez Lazo