Programmed cell death during C. elegans development: Lessons learnt and new things to be discovered
During C. elegans development, 131 cells reproducibly die, and the genetic analysis of these ‘programmed deaths’ was instrumental in the elucidation of the apoptosis pathway (EGL-1 BH3-only, CED-9 Bcl-2, CED-4 Apaf-1, CED-3 caspase), which is conserved from nematodes to humans. Our analysis of the mechanisms through which the activity of the apoptosis pathway is controlled during C. elegans development has uncovered that the C. elegans ‘cell death fate’ is also ideally suited for addressing another fundamentally important question in developmental and stem cell biology and that is how cell fates diverge in the context of asymmetric cell divisions. I will summarise lessons learnt about apoptosis and present an update on our recent studies on cell fate divergence using the C. elegans cell death fate as a paradigm.
Date: 13 June 2022, 12:00 (Monday, 8th week, Trinity 2022)
Venue: Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details: Bioch Phase 2 Ground Floor Main Seminar Room '20-138'
Speaker: Prof Barbara Conradt (University College London)
Organising department: Department of Biochemistry
Organiser: Oxford University Biochemical Society (University of Oxford)
Organiser contact email address: daniel.frey@merton.ox.ac.uk
Host: OUBS (Department of Biochemistry, University of Oxford)
Part of: OUBS seminar series
Booking required?: Not required
Cost: -
Audience: Members of the University only
Editor: Daniel Frey