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Cell cycle governs the self-renewal and differentiation of human pluripotent stem cells
Dr Pauklin studies the molecular mechanisms that govern the stem cell identity of human pluripotent stem cells, and their relevance to tumorigenic processes. He is particularly interested in the function of TGFß/Nodal-Smad2/3 signalling pathway, which has a central role in maintaining pluripotent stem cells and cancer stem cells. Dr Pauklin’s talk will focus on his recent discoveries on cell cycle and epigenetic mechanisms that regulate the self-renewal and differentiation of human pluripotent stem cells (Pauklin 2013 Cell; Pauklin 2016 Genes Dev; Bertero 2015 Genes Dev).
Date:
19 January 2017, 11:00
Venue:
Old Road Campus Research Building, Headington OX3 7DQ
Venue Details:
Ludwig Basement Seminar Room
Speaker:
Dr Siim Pauklin (Wellcome Trust-MRC Stem Cell Institute, Cambridge)
Organising department:
Ludwig Institute for Cancer Research, Oxford Branch
Organiser:
Christina Woodward (Oxford Ludwig Institute, Nuffield Department of Medicine, University of Oxford)
Host:
Prof Xin Lu (Ludwig Cancer Research, Oxford Branch)
Part of:
Ludwig Institute Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Mary Muers
