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There are few stories in science more inspiring than that of Dr Sonia Vallabh and Dr Eric Minikel. After seeing her mother rapidly decline and pass away from prion disease Sonia found out that she also carried the genetic variant that caused the disease. With an unknown timeline until Sonia will likely also succumb to the disease, Eric and Sonia both left their previous careers and retrained as scientists in pursuit of a cure. The Centre for Personalised Medicine is delighted to host Eric and Sonia to tell us more about their story, how they engage with a rare disease community, and their incredible progress towards developing a preventative treatment.