Dr Jinwook Choi 'Friend or Foe: Inflammation in tissue regeneration and diseases'
This seminar is open to members of the University of Oxford only. Please register with your University of Oxford email to ensure a successful registration. Registration is at:https://medsci.zoom.us/meeting/register/tJ0tduiorTwrE9Vd7tf4zFyRKbn1_HSj-CyK
Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and states that are also implicated in tissue dysfunction and pathogenesis. Tissue injury instigates an inflammatory response by modulating immune system in the wound sites, which is essential for restoration of tissue homeostasis. However, signalling between stem cells and immune system is poorly understood. Alveolar type 2 (AT2) cells function as stem cells by self-renewing and differentiating into alveolar type 1 (AT1) cells that are essential for gas-exchange in the lung. However, how AT2 cells are activated from the quiescence and which trajectory they follow to differentiate into AT1 cells remain unknown. Here, we leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories of alveolar lineage cells during injury repair and lung regeneration. We identified how injury remodels immune system and inflammatory niches driven my macrophage dynamics orchestrate tissue regeneration during injury repair in the lungs. We also identified a distinct AT2-lineage population, Damage-Associated Transient Progenitors (DATPs), that arises during alveolar regeneration. Further, we found that chronic inflammation prevents AT1 differentiation, leading to aberrant accumulation of DATPs and impaired alveolar regeneration in chronic human lung diseases.
Date: 5 November 2021, 12:00
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar is open to members of the University of Oxford only and will be held using Zoom. Please register in advance for this meeting: https://medsci.zoom.us/meeting/register/tJ0tduiorTwrE9Vd7tf4zFyRKbn1_HSj-CyK
Speaker: Dr Jinwook Choi (Cambridge University)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Ellen Mobbs (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: reception@kennedy.ox.ac.uk
Host: Professor Tonia Vincent (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJ0tduiorTwrE9Vd7tf4zFyRKbn1_HSj-CyK
Audience: Members of the University only
Editors: Elizabeth Thompson, Ellen Mobbs