How Autophagy Defends the Cytosol Against Bacterial Invasion
Intracellular pathogens inhabit specific cellular niches determined by the degree of compartment-specific immune surveillance and the pathogen’s need for host cell activities and nutrients. Most intracellular bacteria dwell in vacuoles while only few have conquered the cytosol, a perhaps counterintuitive situation considering the abundant energy sources available in the cytosol for bacterial growth. Potent cytosolic defense mechanisms must therefore exist. I will discuss the role of cell-autonomous immunity in defending the cytosol from bacterial invasion, in particular how ‘eat-me’ signals including galectins and ubiquitin become associated with cytosol-invading bacteria, how cells transform the bacterial surface into an anti-bacterial and pro-inflammatory signaling platform, and how cargo-selecting autophagy receptors target cytosolic bacteria for destruction by autophagy.
Date: 24 March 2017, 11:00
Venue: NDM Building, Headington OX3 7FZ
Venue Details: TDI, Basement meeting room, NDM Research Building
Speaker: Professor Felix Randow (MRC Laboratory of Molecular Biology, Cambridge University)
Organising department: Ludwig Institute for Cancer Research, Oxford Branch
Organiser: Christina Woodward (Oxford Ludwig Institute, Nuffield Department of Medicine, University of Oxford)
Organiser contact email address: christina.woodward@ludwig.ox.ac.uk
Host: Dr Mads Gyrd Hansen (Ludwig Cancer Research)
Part of: Ludwig Institute Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editors: Mary Muers, Christina Woodward