OxTalks is Changing
During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
How Autophagy Defends the Cytosol Against Bacterial Invasion
Intracellular pathogens inhabit specific cellular niches determined by the degree of compartment-specific immune surveillance and the pathogen’s need for host cell activities and nutrients. Most intracellular bacteria dwell in vacuoles while only few have conquered the cytosol, a perhaps counterintuitive situation considering the abundant energy sources available in the cytosol for bacterial growth. Potent cytosolic defense mechanisms must therefore exist. I will discuss the role of cell-autonomous immunity in defending the cytosol from bacterial invasion, in particular how ‘eat-me’ signals including galectins and ubiquitin become associated with cytosol-invading bacteria, how cells transform the bacterial surface into an anti-bacterial and pro-inflammatory signaling platform, and how cargo-selecting autophagy receptors target cytosolic bacteria for destruction by autophagy.
Date:
24 March 2017, 11:00
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
TDI, Basement meeting room, NDM Research Building
Speaker:
Professor Felix Randow (MRC Laboratory of Molecular Biology, Cambridge University)
Organising department:
Ludwig Institute for Cancer Research, Oxford Branch
Organiser:
Christina Woodward (Oxford Ludwig Institute, Nuffield Department of Medicine, University of Oxford)
Organiser contact email address:
christina.woodward@ludwig.ox.ac.uk
Host:
Dr Mads Gyrd Hansen (Ludwig Cancer Research)
Part of:
Ludwig Institute Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Mary Muers,
Christina Woodward
