OxTalks is Changing
During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
Using reconstituted systems to understand the composition-dependent molecular clutch between T cell signaling condensates and actin.
The cell plasma membrane and its underlying actin cytoskeleton constitute an active composite system that acts as a platform for multiple tasks such as signal processing, cargo uptake or shape transitions to name a few. Using reconstituted, minimal systems, we expllore how acto-myosin activity drives membrane protein dynamics and vice versa how membrane proteins can affect the actin network organization. Studying LAT-based biomolecular condensates that form during T cell activation, we found that Nck and WASP act as a molecular clutch with actin and that changes in the condensate composition could enable their movement by different actin networks.
Date:
9 March 2020, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Darius Köster (University of Warwick)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Professor Mike Dustin (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Public
Editor:
Jennifer Pope
