Using reconstituted systems to understand the composition-dependent molecular clutch between T cell signaling condensates and actin.
The cell plasma membrane and its underlying actin cytoskeleton constitute an active composite system that acts as a platform for multiple tasks such as signal processing, cargo uptake or shape transitions to name a few. Using reconstituted, minimal systems, we expllore how acto-myosin activity drives membrane protein dynamics and vice versa how membrane proteins can affect the actin network organization. Studying LAT-based biomolecular condensates that form during T cell activation, we found that Nck and WASP act as a molecular clutch with actin and that changes in the condensate composition could enable their movement by different actin networks.
Date:
9 March 2020, 12:00 (Monday, 8th week, Hilary 2020)
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Darius Köster (University of Warwick)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Professor Mike Dustin (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Public
Editor:
Jennifer Pope
