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Deciphering the tumour ecosystem
My research focuses on the emerging concept that tumours are complex, evolving ecosystems with dynamic crosstalk between cancer and normal cells. Understanding how genetically diverse cancer cells adapt to and manipulate their microenvironment is critical for deciphering drivers of cancer progression and evolution. To answer specific questions for a disease type, my team develops new approaches that are fusions of pathological image analysis, bioinformatics and ecological statistics. I will discuss how our study on spatial heterogeneity of immune response led to new appreciation of its clinical relevance in breast cancer within the context of clinical trials, and our recent progress on studying the relationship between microenvironmental diversification and lung cancer evolution in TRACERx.
Date:
29 January 2018, 11:00
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
Basement seminar room, TDI
Speaker:
Dr Yinyin Yuang (Institute for Cancer Research, London)
Organising department:
Ludwig Institute for Cancer Research, Oxford Branch
Organiser:
Christina Woodward (Oxford Ludwig Institute, Nuffield Department of Medicine, University of Oxford)
Organiser contact email address:
christina.woodward@ludwig.ox.ac.uk
Host:
Prof Xin Lu (Ludwig Cancer Research, Oxford Branch)
Part of:
Ludwig Institute Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Christina Woodward
