Pushing and pulling: Centrosome positioning in polarized cells
Asymmetric cell division, where daughter cells inherit unequal amounts of specific factors, is critical for development and cell fate specification. In polarized cells, where specific factors are segregated to opposite ends of the cell, asymmetric cell division occurs as a result of positioning the centrosomes along the polarity axis. Using an individual-based stochastic model of centrosome-associated microtubule dynamics and experiments in early embryos of the nematode worm C. elegans, we explore potential sources of force generation and demonstrate the role of both cortical and centrosomal asymmetries for recapitulating the in vivo dynamics and proper positioning of the centrosomes prior to first division.
Date: 4 March 2020, 13:00 (Wednesday, 7th week, Hilary 2020)
Venue: Sir William Dunn School of Pathology, South Parks Road OX1 3RE
Venue Details: EPA Seminar Room
Speaker: Dr Adriana Dawes (Dept of Mathematics, The Ohio State University)
Organising department: Sir William Dunn School of Pathology
Organiser: Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address: melissa.wright@path.ox.ac.uk
Host: Dr Omer Dushek (Sir William Dunn School of Pathology, Oxford)
Part of: Dunn School of Pathology Research Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Melissa Wright