OxTalks is Changing
During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
How cells defend their cytosol against bacteria: LPS ubiquitylation and other tricks
In-person
Intracellular pathogens colonize specific subcellular niches, determined by their need for host-derived nutrients and their ability to overcome compartment-specific immune responses. Most intracellular bacteria reside in phagosomes, with only a few species managing to colonize the cytosol. This is somewhat counterintuitive, given the abundance of nutrients freely available in the cytosol. Therefore, potent cytosolic defense mechanisms must exist. I will discuss how cells protect their cytosol against bacterial invasion through autophagy, focusing on novel triggers for antibacterial autophagy that we have discovered: the detection of sphingomyelin on damaged phagosomes by TECPR1, and the ubiquitylation of LPS on Gram-negative bacteria by RNF213. I will also explore how cytosol-adapted bacteria counteract antibacterial autophagy
Date:
13 January 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Felix Randow (MRC Laboratory of Molecular Biology, Cambridge, UK)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Katie Roberts (University of Oxford),
Jo Silva (NDORMS)
Organiser contact email address:
katie.roberts@kennedy.ox.ac.uk
Host:
Jelena Bezbradica Mirkovic (KTRR SENIOR RESEARCH FELLOW)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Katie Roberts