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Inflammasomes are multimolecular protein complexes that catalyse key inflammatory reactions in response to pathogens and to tissue injury. Understanding the regulation of inflamamsomes has led to the development of new anti-inflammatory drugs that may be effective in a number of diseases. Here Prof Brough describes recent work on the formation and degradation of the NLRP3 inflammasome, and also covers some recent work on the AIM2 inflammasome.
