On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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Abstract:
Almost every eukaryotic mRNA has a 3’ polyA tail that contributes to post-transcriptional regulation of gene expression by regulating translation and mRNA stability. My laboratory studies the macromolecular protein complexes that control addition and removal of polyA tails: CPF, Ccr4–Not and Pan2–Pan3. We use a hybrid approach combining structural (cryo-EM, x-ray crystallography, NMR), biochemical, biophysical and genetic techniques to gain insights into their molecular mechanisms. I will discuss structural and mechanistic studies that have provided insights into the functions of these complexes. In addition, I will discuss recent advances in specimen preparation for electron cryo-microscopy (cryo-EM) that we are using to study these complexes.
