Elucidation of a set of validated physiological substrates for the Parkinson’s LRRK2 kinase
Dario Alessi was born in France, attended high school in Brussels and obtained a BSc in Biochemistry from the University of Birmingham, UK in 1988. He received a Ph.D. in 1991 for work on the synthesis and use of spin-labelled ATP analogues to study muscle contraction under the joint supervision of Ian Trayer (University of Birmingham) and David Trentham FRS (National Institute of Medical Research, Mill Hill, London). He then carried out postdoctoral research with Sir Philip Cohen FRS in the MRC Protein Phosphorylation Unit at Dundee from 1991 to 1997, where he became fascinated by protein kinases and how they control almost all aspects of cell biology.
In 1998 Dario became a Programme Leader in the MRC Protein Phosphorylation Unit, and assumed the Directorship of the Unit in April 2012. A key focus of his current research is to understand the regulation and physiological roles of poorly understood protein kinases and components of the ubiquitylation system that implicated in human disease. Dario is very keen to exploit findings emerging from his studies to develop novel treatments for disease.
In March 2013 Dario’s lab have published over 210 peer-reviewed research papers/reviews that have accumulated more than 33000 citations. Dario’s Alessi’s h-index is 86 (i.e. 86 papers cited >86 times, with 80 papers cited over 100 times).
In March 2010 Dario Alessi was ranked as 16th most cited biochemist worldwide.
19 January 2016, 16:00 (Tuesday, 1st week, Hilary 2016)
Sherrington Building, off Parks Road OX1 3PT
Sherrington Library, 2nd floor (note main door closes at 4pm)
Prof. Dario Alessi (MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee)
Department of Physiology, Anatomy and Genetics (DPAG)
Melanie Witt (University of Oxford, Department of Earth Sciences, Department of Physiology Anatomy and Genetics)
Organiser contact email address:
OPDC Seminar Series (DPAG)
Members of the University only