Seminar by Dr Dan Woodcock "The evolution of prostate cancer disease types"
Cancer progression is an evolutionary process involving the sequential occurrence of key genetic alterations known as drivers. In prostate cancer, progression to metastasis requires multiple driver alterations, although the type and order of these invariably differs between patients. In this talk we describe how the union of multiple genomic analyses reveals that divergent evolution, mediated by drivers that induce dysregulation of androgen receptor DNA binding, results in two distinct subtypes. Our findings unify many previous molecular groupings in prostate cancer and provide a powerful new paradigm for cancer stratification.
Date: 23 January 2023, 12:00 (Monday, 2nd week, Hilary 2023)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held in the Kennedy Lecture Theatre with the option to join via Zoom at https://medsci.zoom.us/meeting/register/tJwlce-srTIoH9BASDMXlz5WETFbiNlFEAX7
Speaker: Dr Dan Woodcock (University of Oxford)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Ellen Mobbs (Kennedy Institute of Rheumatology), Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: ellen.mobbs@kennedy.ox.ac.uk
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJwlce-srTIoH9BASDMXlz5WETFbiNlFEAX7
Audience: Members of the University only
Editor: Ellen Mobbs