Inflammation Shapes Lung Regeneration
In the lung, alveolar type II cells behave as stem cells by regenerating alveolar type I cells after injury. However, underlying cellular and molecular mechanisms that awake the quiescent stem cells and orchestrate the regeneration process remain unclear. Here, we use single-cell RNA sequencing, in vivo lineage tracing, and ex vivo lung organoid co-cultures to define the functional impact of inflammatory niche on stem cell behaviours during regeneration process after injury.
Date: 1 July 2019, 12:00 (Monday, 10th week, Trinity 2019)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Dr Joo-Hyeon Lee (University of Cambridge)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jo Silva (NDORMS), Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
Host: Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Jennifer Pope