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Inflammation Shapes Lung Regeneration
In the lung, alveolar type II cells behave as stem cells by regenerating alveolar type I cells after injury. However, underlying cellular and molecular mechanisms that awake the quiescent stem cells and orchestrate the regeneration process remain unclear. Here, we use single-cell RNA sequencing, in vivo lineage tracing, and ex vivo lung organoid co-cultures to define the functional impact of inflammatory niche on stem cell behaviours during regeneration process after injury.
Date:
1 July 2019, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Joo-Hyeon Lee (University of Cambridge)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Jo Silva (NDORMS),
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
Jennifer.Pope@kennedy.ox.ac.uk
Host:
Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Jennifer Pope
