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Mechanisms of DNA processing machines - from transcription initiation to DNA damage repair
We are interested in structures and molecular mechanisms that govern how genetic information is accessed through transcription and how damaged DNA is detected and repaired. Transcription is carried out by the multi-subunit RNA polymerase (RNAP) and is a highly regulated process. We are particularly interested in transcription initiation which is highly dynamic. We use a special form of bacterial RNAP, which allows us to trap intermediate states during transcription initiation. I will discuss our current understanding of the molecular mechanisms of transcription initiation process including how DNA is opened up and delivered into the active centre for transcription. I will also discuss our progress towards understanding key components involved in DNA damage signalling and repair.
Date:
22 November 2019, 14:00
Venue:
Medical Sciences Teaching Centre, off South Parks Road OX1 3PL
Venue Details:
Lecture Theatre
Speaker:
Professor Xiaodong Zhang (Imperial College, London)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Dawn Gibbons (Sir William Dunn School of Pathology )
Organiser contact email address:
dawn.gibbons@path.ox.ac.uk
Host:
Dr Fumiko Esashi (University of Oxford )
Part of:
Dunn School of Pathology Departmental Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Dawn Gibbons
