Protecting motor neurons from degeneration by targeting bioenergetics
Hybrid event - please contact chelsea.larabee@idrm.ox.ac.uk to receive the online link.
Finding novel treatments that protect motor neurons from degeneration remains a cornerstone of therapeutic development for motor neuron diseases such as ALS and SMA. In this talk I will present my lab’s identification of bioenergetics pathways as important, endogenous regulators of motor neuron stability in vivo. I will discuss how activation of PGK1 represents an attractive therapeutic in this regard, and present ongoing work to translate pre-clinical findings into clinical trials for patients with ALS.
Date:
19 October 2023, 11:30 (Thursday, 2nd week, Michaelmas 2023)
Venue:
John Radcliffe West Wing and Children's Hospital, Headington OX3 9DU
Venue Details:
Level 6
Speaker:
Tom Gillingwater (University of Edinburgh)
Organising department:
Divisional Office (MSD)
Organiser:
MDUK Oxford Neuromuscular Centre (University of Oxford)
Organiser contact email address:
chelsea.larabee@idrm.ox.ac.uk
Host:
Professor Kevin Talbot (University of Oxford)
Part of:
MDUK Oxford Neuromuscular Centre Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Chelsea Larabee
