New connections between chromatin, the cell cycle and cancer
Whereas the general principles of dynamic cell cycle regulation are now well understood, we know much less about their coordination in space and with the organisation of the nucleus. In this talk, I will present two short stories of our latest results demonstrating cell cycle regulation of chromatin and its importance in cancer. The first is about a novel phosphorylation of histone H3 that we have discovered and its involvement in maintaining genome stability during DNA replication, and the second concerns the ubiquitous mammalian cell proliferation marker, Ki-67, that we have found links heterochromatin to the cell cycle and senescence.
Date: 19 February 2015, 11:00 (Thursday, 5th week, Hilary 2015)
Venue: NDM Building, Headington OX3 7FZ
Venue Details: Basement Seminar Room
Speaker: Daniel Fisher (PhD)
Organising department: Target Discovery Institute
Organisers: Andrea Keyte (University of Oxford, Target Discovery Institute), Claire Escher Kessler (University of Oxford, NDM Strategic)
Part of: TDI Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editor: Anne Bowtell