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Advances in Vaccines and Antibodies for Blood-Stage Malaria
Two vaccines are now approved for use against Plasmodium falciparum malaria in young African children; these can prevent liver infection. However, if a single parasite slips through the net, blood-stage infection is established causing clinical disease. An effective blood-stage vaccine (or second line of defence), however, has proved elusive. We have developed vaccines targeting the P. falciparum RH5 antigen, which mediates a conserved and essential invasion pathway into the human red blood cell. Rational vaccine design has built on our understanding of how vaccine-induced anti-RH5 human antibodies inhibit parasite growth. This talk will describe our work to understand human anti-malarial antibodies and present data from Phase 1/2 clinical trials of RH5-based blood-stage vaccines undertaken in the UK and across Africa.
Date:
25 November 2024, 13:00
Venue:
Biology South Parks Road, South Parks Road OX1 3RB
Venue Details:
(former Plants Sciences Building) - Large Lecture Theatre. Building has receptionists
Speaker:
Prof Simon Draper (Department of Biochemistry)
Organising department:
Department of Biology
Organiser:
Andrea Kastner (Department of Biology)
Organiser contact email address:
andrea.kastner@biology.ox.ac.uk
Host:
Prof Sunetra Gupta (Department of Biology)
Booking required?:
Not required
Cost:
Free
Audience:
Members of the University only
Editor:
Andrea Kastner
