Is there a new treatment option for ectopic pregnancy on the horizon?
This talk will take place on MS Teams, please contact the organiser for the link should you wish to join

Andrew Horne, PhD, FRCOG, FRCP Edin, FRCSEd, FRSE
Professor of Gynaecology and Reproductive Sciences, MRC Centre for Reproductive Health, University of Edinburgh, UK
Professor Horne’s research interests include understanding the causes of ectopic pregnancy and investigating novel methods for treatment, as well as investigating the aetiology, and researching novel treatment approaches, of persistent pelvic pain and endometriosis.


Is there a new treatment option for ectopic pregnancy on the horizon?

Ectopic pregnancies are a serious gynaecological emergency that can be fatal. As such, prompt diagnosis and safe timely treatment is essential. In this lecture, I will present preclinical studies and clinical trials of a new molecularly targeted therapeutic approach for ectopic pregnancy: the use of combination gefitinib (orally available epidermal growth factor receptor inhibitor) and methotrexate. Our preclinical studies suggest that combination gefitinib and methotrexate is highly effective in inducing placental cell death, and is significantly more effective than methotrexate alone. In our early human trials, encouraging preliminary efficacy data have shown that combination gefitinib and methotrexate can rapidly resolve tubal ectopic pregnancies, and large extra-tubal ectopic pregnancies. If our large multicentre randomized controlled trial confirms these findings, combination gefitinib and methotrexate could become a new medical treatment option for ectopic pregnancy.
Date: 18 January 2022, 13:00 (Tuesday, 1st week, Hilary 2022)
Venue: Venue to be announced
Speaker: Professor Andrew Horne (The University of Edinburgh)
Organising department: Nuffield Department of Women's and Reproductive Health
Organiser: Dr Jen Southcombe (University of Oxford)
Organiser contact email address:
Booking required?: Not required
Booking email:
Audience: Members of the University only
Editor: Danielle Hoare