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Multiple tightly orchestrated cell migration events underlie every B cell response. Our work on chemokines and lipid mediators supporting T-dependent B cell responses will be reviewed. This will include updates on the human germinal center confinement receptor P2RY8, and the adhesion GPCR, CD97, and its role in dendritic cell and B cell positioning in the spleen. Early during inflammation, CCL21 is downregulated in lymph nodes, yet B and T cell recruitment continues, and this is important to ensure sufficient precursors are present to respond. We find that inflammation switches the chemoattractant code for naïve lymphocyte entry into lymph nodes. Our ongoing work on this topic will be presented.
