Use of network theory to define optimal HIV immune targets: Implications for immunologic control and immunogen design
Viral diversity remains a major challenge to HIV vaccine development. By applying concepts rooted in network theory to viral protein structure, we have developed an algorithm that identifies amino acid residues critical to the structure and function of HIV proteins. Functional data from persons who control HIV without medications demonstrate preferential CD8+ T cell recognition of highly networked residues predicted by the algorithm. Application of this knowledge to inform a rational T cell-based vaccine for HIV will be discussed.
Date: 15 September 2017, 14:00 (Friday, 21st week, Trinity 2017)
Venue: Medawar Building, off South Parks Road OX1 3SY
Venue Details: Level 30 seminar room
Speaker: Professor Bruce Walker (Ragon Institute of MGH, MIT and Harvard)
Organising department: NDM Experimental Medicine
Organiser: Prof. Philip Goulder (University of Oxford)
Host: Prof. Philip Goulder (University of Oxford)
Booking required?: Not required
Audience: Members of the University only
Editor: Lynn Dustin