Activation and regulation of innate immune responses to viral DNA

Søren Riis Paludan’s laboratory focuses on how the immune system recognizes virus infections and how this leads to an immune response. They aim to improve understanding of how the immune system works and interacts with viruses, and how this impacts on the pathogenesis of viral infections. Such work may lead to better understanding of viral diseases and could have implications for future development of improved vaccines, antiviral therapeutics, and diagnostic tools. The main areas of work focus on: mechanisms of viral detection by the innate immune system and viral means to evade these processes; interactions between the innate immune system and basic cellular processes, and the impact on host defense and development of disease; mechanisms of host defense in animal models for human diseases.