OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Seminar by Dr Venizelos Papayannopoulos "Chromatin’s life after death"
This seminar will be held via Zoom. Open to all oxford University members. Registration with valid Oxford uni email address at: https://medsci.zoom.us/meeting/register/tJAvcO-vrD8tE9TjZq4aCJm43CqkJ_y74C0R
The talk will explore the role of extracellular chromatin in driving immune pathology in chronic and acute inflammatory conditions. Chromatin plays distinct proinflammatory roles during atherosclerosis but is also detrimental during sepsis and other severe conditions. However, the mechanisms regulating the release of cell free chromatin and its modes of action are unclear. We will first discuss the role of extracellular chromatin in driving neutrophil extracellular trap-driven inflammation and highlight its mechanisms of action. We will then explore the sources of cell free chromatin in sepsis and the events occurring in the spleen that lead to its release during systemic infection. Our recent data uncover a model where the capture of microbes by splenic macrophages sets off a pathogenic programme with extracellular chromatin at its epicentre, that promotes hyper-inflammation and immune dysfunction in the innate and adaptive compartment during sepsis. Finally, we will discuss the impact of chromatin clearance pathways in the regulation of pathology during acute infections.
Date:
4 April 2022, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held via Zoom. Open to all oxford University members. Registration with valid Oxford uni email address at: https://medsci.zoom.us/meeting/register/tJAvcO-vrD8tE9TjZq4aCJm43CqkJ_y74C0R
Speaker:
Dr Venizelos Papayannopoulos (The Francis Crick Institute, London)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
ellen.mobbs@kennedy.ox.ac.uk
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://medsci.zoom.us/meeting/register/tJAvcO-vrD8tE9TjZq4aCJm43CqkJ_y74C0R
Audience:
Members of the University only
Editors:
Elizabeth Thompson,
Ellen Mobbs
