The Double Burden of Diabetes and Global Infection
Four out of five people in the world with diabetes now live in low- and middle-income countries (LMIC), and the incidence of diabetes is accelerating in poorer communities. Diabetes increases susceptibility to infection and worsens outcomes for some of the world’s major infectious diseases such as tuberculosis, melioidosis and dengue, but the relationship between diabetes and many neglected tropical diseases is yet to be accurately characterised. There is some evidence that chronic viral infections such as hepatitis B and HIV may pre- dispose to the development of type 2 diabetes by chronic inflammatory and immunometabolic mechanisms. Helminth infections such as schistosomiasis may be protective against the development of diabetes, and this finding opens up new territory for discovery of novel therapeutics for the prevention and treatment of diabetes. A greater understanding of the impact of diabetes on risks and outcomes for infections causing significant diseases in LMIC is essential in order to develop vaccines and therapies for the growing number of people with diabetes at risk of infection, and to prioritise research agendas, public health interventions and policy.
Date: 18 March 2019, 12:00 (Monday, 10th week, Hilary 2019)
Venue: Big Data Institute (NDM), Old Road Campus OX3 7LF
Venue Details: Seminar room 0
Speaker: Susanna Dunachie (University of Oxford)
Organising department: Big Data Institute (NDM)
Organisers: Chantal Hendriks, Will Probert (University of Oxford )
Organiser contact email address: chantal.hendriks@bdi.ox.ac.uk
Part of: Infections@BDI
Topics:
Booking required?: Not required
Audience: Members of the University only
Editor: Chantal Hendriks