High-throughput mass spectrometry for drug discovery

Matthias Trost is a proteomics expert with interests in innate immunity and drug discovery. He studied chemistry in Freiburg, Germany and Manchester, UK. He has a PhD in Cellular Microbiology & Proteomics from the Helmholtz Centre for Infection Research, Braunschweig, Germany and was a postdoctoral fellow with Michel Desjardins and with Pierre Thibault, Institute for Research in Immunology and Cancer, Montreal, Canada. In 2010, he became Programme Leader and Head of Proteomics at the MRC Protein Phosphorylation & Ubiquitylation Unit at the University of Dundee, UK. Since 2017, he is Professor of Proteomics at Newcastle University. Matthias’s research utilises mass spectrometry and proteomics to understand innate immunity in macrophages. He also has a strong interest in drug discovery for which his lab pioneered high-throughput MALDI TOF mass spectrometry approaches. In 2019, he was given a Wellcome Investigator Award to study how ubiquitylation regulates innate immune functions at the phagosome of macrophages.