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Cell Shape Sensing by Immune Cells
In person only
Immune cells experience large deformation events while paroling their environment. These cell shape changes arise from the continuous physical constraints encountered during migration within tissues and organs. It has become increasingly clear that these cells can survive and adapt to changes in cell shape using dedicated shape-sensing pathways. However, how shape sensing impacts their behavior and function remains largely unknown. During my seminar, I will show unpublished data highlighting that the nuclear shape changes experienced by immune cells define their migratory behavior and immunoregulatory properties, revealing the contribution of the physical properties of tissues to tuning of the balance between tolerance an immunity.
Date:
25 April 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Lecture Theatre
Speaker:
Dr Ana-Maria Lennon-Duménil (Institut Curie, Paris)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
