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The overarching focus of my research program is understanding how the immune system can respond to multiple inflammatory insults at the same time. My laboratory has two main interrelated areas of focus: 1) understanding how coinfection with respiratory viral pathogens and bacteria or severe single infections compromises the innate immune response and host disease tolerance and 2) how lung infections compromise the immune response in a healing wound. I will address both these topics today in the context of the lung as a central regulator of not only the pulmonary immune response, but systemic responses during infection and injury.
